• Increases endorphin levels

  • Overall better mood and feeling of well being

  • Modulates the immune system

  • Lowers markers of inflammation in the body

  • Reduces fatigue and brain fog

  • Clinical evidence in reducing chronic pain 

  • Encourages weight loss in some patients

Longevity Benefits

LDN has not been approved by FDA for these uses, but there are multiple scientific studies that have shown these benefits.

Purchase LDN

  1. Complete medical intake form

  2. Receive medical approval or follow-up

  3. Get medication shipped to your door

Starting at - $35/Month

* Prescription products, such as LDN,  require an online consultation with a physician to determine if a prescription is appropriate. See below for important safety information. Benefits outlined on Agelessrx.com are based on third party studies. LDN is offered as a subscription service you can cancel at any time.

* For refills, click here.


  • Low Dose Naltrexone (LDN) works with your endorphin and immune systems to reduce overall oxidative stress—targeting a number of age-related mechanisms. Various scientific research and use cases over the last 40 years suggest LDN can help to improve the body's ability to defend against age-related diseases.

Background & History

Aging Pathways Impacted

  • Genomic Instability

  • Loss of Protasis

  • Mitochondrial Dysfunction

  • Low Dose Naltrexone (LDN) refers to prescribed doses below 10mg per day (4.5mg/daily is most common)

  • Naltrexone has been prescribed for over 40 years with an outstanding safety record at doses 10-20x above LDN

  • When administered in low doses, Naltrexone exhibits novel and paradoxical effects for a variety of conditions

  • As discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center in 1980, Naltrexone also has effects against cancer

  • Naltrexone was approved by the FDA in 1985 to treat opiate dependencies at dosages between 50mg-100mg per day

  • Since 1985, LDN has also been used to treat autoimmune diseases and viral infections

  • Later, the FDA also approved the drug to treat obesity and weight loss

  • Hundreds of clinical studies have shown LDN to reduce inflammation

  • Dr. Z, Chief Medical Officer at AgelessRx, has prescribed LDN for years with successful results in a variety of patients . Learn More


26 Year Old Female

Saint Joseph, MO

It has cut my joint pain in half, helped me lose weight, improved my memory (fibro fog), and made me feel like a happier person.

LDN had helped reduce inflammatory issues from IBS as well as decrease joint aches/pains.

44 Year Old Female

Davis, OK

While on LDN, I was mostly pain free... I wasn't as tired during the day and I felt better emotionally. I didn't notice any side effects and felt great.

45 Year Old Female
San Bernardino, CA

I have hypothyroid issues, adrenal, mood, and get ill easily. Ever since LDN, it has significantly helped with all of these, easing or eliminating the many symptoms and reducing my dependence and need for other meds.

83 Year Old Female

Alton, MO

Have had less [arthritis] pain, more energy, calmer and just feel better in general.

71 Year Old Male

Bridgeport, TX

Improved my ability to sleep and a general sense of feeling better overall.

48 Year Old Female

Sun City Center, FL

Your individual results may differ from the above testimonials.

Important Safety Information & Common Side Effects

  • Vivid dreams

  • Mild anxiety

  • Insomnia

  • Headache

During the first three to five days of taking LDN, you may experience mild to moderate levels of the above side effects. Side effects typically diminish on their own by day five. To reduce the risk of side effects, the recommended protocol is to start with a ½ tab (2.25mg) for the first two weeks with a gradual increase to the 4.5mg dose.

If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to your doctor who prescribes your thyroid medication.

Note:  Please stop taking any dosage of Naltrexone a minimum of 48-hours before any surgical procedure or medical diagnostic requiring sedation, such as surgery or a colonoscopy. If you are not sure if you need to stop Naltrexone, please ask your doctor ordering the test or procedure. Additionally, Naltrexone cannot be taken in conjunction with opioids/painkillers. If you need to stop taking Naltrexone for a surgery, and accompanying pain killers are prescribed, you may resume LDN only 48-hours after you take your last painkiller. 

For a full list of possible side effects Click Here​

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*If you are interested in a prescription product, AgelessRx will assist in setting up a visit for you with a licensed physician, who will evaluate whether or not you are an appropriate candidate for the prescription product. If appropriate, he/she may write you a prescription for the product which you can fill at the pharmacy of your choice.