METFORMIN - SCIENCE & RESEARCH

  • Oral diabetes medicine that helps control blood sugar levels

  • FDA approved drug to treat diabetes

  • A pill, derived from natural compounds in the French Lilac plant

  • Used successfully for over 60 years with an outstanding safety record

  • On the World Health Organization’s Model List of Essential Medicines, a catalog of the most effective, safe, and cost-effective therapies

Background & History

Longevity Benefits

  • Lowers risk of colon & pancreatic cancer

  • Reduces risk of cognitive impairment

  • Lowers rate of dementia

  • Reduces risk of macrovascular disease

  • Provides weight loss in some patients

  • Reduces chances of diabetes

Note: Metformin has not been approved by FDA for these uses, but there are multiple  studies that have shown these benefits, see below.  Learn more about "of label" uses

RESEARCH & STUDIES

Can People with Type 2 Diabetes Live Longer Than Those Without?

Surprisingly, yes they can, if they are treating it with metformin. This was the finding of a study of 78k people with type 2 diabetes, compared to a control group of 78k people without diabetic controls. Patients with type 2 diabetes who were taking Metformin had longer survival than did  non-diabetic control matches.

 

Click here to see the study.

Cancer Risk

A retrospective study of 62k patients in UK: “Metformin use was associated with lower risk of cancer of the colon or pancreas..."

A representative population study of 800k individuals: "Metformin can reduce the incidences of several gastroenterological cancers..."

A study conducted at M.D. Anderson Cancer Center involving 973 patients and 863 controls: "Metformin use was associated with reduced risk of pancreatic cancer..."

A retrospective study of 3,800 men conducted in Ontario, Canada: "Increased cumulative duration of metformin exposure after Prostate Cancer diagnosis was associated with decreases in both all-cause and Prostate Cancer-specific mortality..."

A study involving 1,300 patients in Netherlands: "Metformin use was associated with lower cancer mortality compared with non users..."

A case-control study of 450K US veterans who underwent colonoscopy between 1999 and 2014: "Metformin was associated with a 14% statistically significant reduced rectal cancer odds ..."

Metformin is Associated with a Higher Cancer Survival Rate

Ovarian Cancer

A Mayo Clinic study evaluated the association between metformin and the prognosis in ovarian cancer across 240 women (60 cases and 178 controls). Study had a heavy emphasis on the survival comparisons between diabetic women who had ovarian cancer and took metformin (cases) and non-diabetic women who had ovarian cancer (controls).  "The results from our study demonstrate that metformin intake independently predicts better survival in patients with ovarian cancer."

Ovarian Cancer is the 5th most common cancer in women, and the deadlest with a mortality rate of 65%

Diabetic women who took metformin had better survival than nondiabetic women who did not take metformin.

Metformin is Associated with a Higher Ovarian Cancer Survival Rate

Cognitive Impairement

A study of 365 people aged 55 and over, who were followed for 4 years: "Controlling for age, education, diabetes duration, fasting blood glucose, vascular and non-vascular risk factors, Metformin use showed a significant inverse association with cognitive impairment."

A study of 67,731 participants who were non-demented, non-diabetic, aged 65 or over at baseline, from January 2004 to December 2009: "Diabetes is associated with an increased risk of dementia. The risk effect becomes weaker provided that participants take sulfonylureas or Metformin rather than thiazolidinediones for a longer period"

Diabetes Prevention

A diabetes Prevention Program Group study showed that lifestyle intervention or metformin significantly reduced diabetes development over 15 years. "At year 15, the cumulative incidences of diabetes were 55% in the lifestyle group, 56% in the metformin group, and 62% in the placebo group." 

Metformin Delays and Prevents Diabetes Development

Macrovascular

A study of 390 patients in a randomized, placebo-controlled trial with a follow-up period of 4.3 years: "Metformin did, however, reduce the risk of macrovascular disease after a follow-up period of 4.3 years..."

Weight Loss

A study of 154 patients over a 6 month period in Germany: "Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients..."

Fertility

A study of 43 women in Ohio: "Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndromes..."

How Metformin works on a cellular level in relation to aging

For an organism to survive, there has to be a balance between the anabolic processes which generate energy, and catabolic processes that use this energy for fuel. The balance is especially important when energy intake is low and cells don’t have an adequate supply to meet the demand. In such cases, organisms avoid crisis by implementing biological austerity measures, reallocating limited resources from growth and reproduction to self-preservation and survival. Significantly, organisms in this “thrifty” state show remarkable resistance to multiple age-onset pathologies.

 

Metformin delivers this effect by limiting metabolic reactions in mitochondria, thereby slowing down the process by which our cellular powerhouses convert macronutrients to energy. This results in less ATP production, which in turn activates AMPK, an enzyme that senses when a cell has low energy levels. When low levels are detected, AMPK activates multiple pathways to implement biology austerity measures, promoting several energy production benefits, including:

HOW IT WORKS

AGING PATHWAYS IMPACTED

AGING PATHWAYS IMPACTED

In 2013 a team of researchers broke down the causes of aging into 9 distinct scientific "hallmarks" (Aging Pathways) and explained how these interact with each other to drive the onset of age-related diseases.  ​

​Hallmarks Impacted by Metformin

  • Genomic Instability

  • Epigenetic Alteration

  • Deregulated Nutrient Sensing

  • Cellular Senescence

9 Hallmarks of Aging

Genomic Instability

Telomere Attrition

Epigenetic Alteration

Loss of Proteostasis

Deregulated Nutrient Sensing

Mitochondrial Dysfunction

Cellular Senescence

Stem Cell Exhaustion

Altered Intercellular Communication

SAFETY & SIDE EFFECTS

Most Common side effects of metformin: 

  • Gastrointestinal discomfort (diarrhea, nausea, bloating)

  • Reduction of Vitamin B12 levels, please supplement Vitamin B12

Most people start with a small dose to avoid stomach discomfort (½ or 1 tablet per day with food, increasing to what has been prescribed on the bottle). We commonly use the extended release (ER) version of metformin to reduce stomach discomfort.

Note:  Metformin is commonly stopped a week before any surgical procedure or medical diagnostic requiring contrast, such as a CT scan.  If you are not sure if you need to stop metformin, please ask the doctor ordering the test or procedure.

For a full list of possible side effects Click Here​

DRUG INTERACTIONS

  • Tell your doctor and pharmacist if you are allergic to metformin, any of the ingredients of metformin liquid or tablets, or any other medications. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); digoxin (Lanoxin); diuretics ('water pills'); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); medications for asthma and colds; medications for mental illness and nausea; medications for thyroid disease; morphine (MS Contin, others); niacin; oral contraceptives ('birth control pills'); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); quinine; ranitidine (Zantac); triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol); or vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

PURCHASE METFORMIN

  1. Complete medical intake form

  2. Receive medical approval (or follow-up)

  3. Get medication shipped to your door

Purchase Process

Starting at - $25/Month

* Prescription products require an online consultation with a physician who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on agelessrx.com are based on 3rd party studies. Metformin is offered as a subscription service you can cancel at any time.

*If you are interested in a prescription product, AgelessRx will assist in setting up a visit for you with a licensed physician, who will evaluate whether or not you are an appropriate candidate for the prescription product. If appropriate, he/she may write you a prescription for the product which you can fill at the pharmacy of your choice.