NAD Science and Research

SCIENCE & RESEARCH

NAD+

Background & History

  • Discovered by Nobel Prize-winning British biochemists in 1906 

  • The availability of NAD+ has shown to promote DNA health and repair

  • NAD+ is required to deactivate genes that accelerate aging

  • Unfortunately, scientific studies show that NAD+ levels decline significantly with age

  • Historically the most effective way to boost NAD+ was through expensive infusions; pills have been shown to be less effective

  • AgelessRx offers new methods of delivery (e.g. patch, nasal spray, injection, and cream) that are effective, less expensive and more convenient than other treatments

Longevity Benefits

  • Promotes cellular energy production 

  • Supports DNA health and repair

  • Required to “turn off” genes that accelerate degenerative aging processes

Research & Studies

Harvard Medical School Study Shows NAD+ Boosting in Mice Decreased Aging

"They focused on an intriguing compound with anti-aging properties called NAD+...It's been known that younger mice had more of it than older mice and back in 2013, the researchers found that when they boosted the NAD+ levels in older mice, they looked, biologically, like much younger animals." - TIME

Longevity

When NAD+ levels rise, Sirtuins are activated. Sirtuins are enzymes that influence aging and longevity. They regulate a variety of metabolic processes, including the release of insulin, stress response, and modulation of lifespan.

 

The David Sinclair lab at Harvard Medical school has done extensive research into the benefits of NAD+ on aging and age related-diseases. Read the Studies

DNA Repair

When damaged, DNA activates an enzyme known as PARP-1 that carries out DNA repair within cells. NAD+ is required for PARP-1 to be activated.

PARP-1 activity correlates with maximum lifespan in mammals. The higher the PARP-1 activity, the longer the lifespan. Read Full Study

Cells from centenarians (people who are at least 100 years old) show significantly higher PARP-1 activity levels than those of average 70 year olds. 

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NAD+ Impact on Multiple Diseases

A Study done by the Developmental Biology department at the Washington University of School of Medicine found that the dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. 

Age related diseases that show a strong correlation with decreases of NAD+ include:

  • Diabetes

  • Non-alcoholic fatty liver disease

  • Atherosclerosis

  • Alzheimer's disease

  • Retinal degeneration

  • Depression

How It Works

NAD+ Works on a Cellular Level in Relation to Aging

Nicotinamide adenine dinucleotide (NAD+) is an important cofactor in all living cells, involved in fundamental biological processes including metabolism, cell signaling, gene expression, DNA repair, and more.

 

Systemic NAD+ decline is one of the fundamental molecular events that negatively impacts the process of aging, potentially limiting lifespan.​

  • NAD+ is required for energy production through metabolism, and helps turn nutrients into energy - without NAD+, we cannot make energy. 

  • NAD+ is required for energy production in every tissue, including the brain, immune cells, muscles, and more.

  • It is a required “helper” molecule for proteins that regulate other cellular functions.

  • Availability of NAD+ in the body promotes DNA repair, while NAD+ decline is associated with accumulation of DNA damage.

  • NAD+ levels decrease across multiple types of tissues with age, a factor associated with many hallmarks of aging.

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Source: Improving Health Through NAD+ Boosting - The Sinclair Lab

Important Safety Information

Since extra niacinamide needs to be methylated in order to be excreted, there is a theoretical need for extra methyl donors when using NAD+. We recommend using trimethylglycine (TMG also known as betaine), 500 to 1000mg, either daily, or at least on the days when the NAD+ patch is used. TMG is easily obtainable on Amazon or any other vitamin retailer.

You can see a number of TMG options here. This is the cheapest we found.

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Explore NAD+ Support

NAD+ INJECTION

  • 500 or 1,000/mg of NAD+ solution & syringes

  • Improves energy levels, mental clarity & mood

  • Effective in reducing cravings & fatigue

  • Improves post workout recovery

  • More cost-effective & convenient than IV infusions

  • Administered 1-3 times a week

Starting at $250

NAD+ Injection

Starting at $250

NAD+ PATCHES

  • 400mg of NAD+ Solution per patch

  • Battery powered iontophoresis patch drives NAD+ absorption

  • Improves energy levels, mental clarity & mood

  • Supports DNA health and repair

  • Required to turn off genes that accelerate degenerative aging

  • Administered weekly 

Starting at $160/kit

NAD+ Patch

Starting at $160/Kit

NAD+ NASAL SPRAY

  • 14 ml bottle with 300 mg/ml NAD+ concentration 

  • Improves energy levels, mental clarity & mood

  • Effective in reducing cravings & fatigue

  • Convenient way to boost brain NAD levels

  • Administered as needed

Starting at $125/Month

NAD+ Nasal Spray

Starting at $125/Month

NAD+ FACE CREAM

  • 15 gm pump infused with 10% NAD+ concentration

  • Lessens appearance of wrinkles & age spots

  • Improves skin elasticity & firmness

  • Reduces sun sensitivity & future UV damage

  • Administered Daily

NAD Face Cream 15GM

Starting at $95