NAD+ SCIENCE & RESEARCH

Background & History

  • Discovered by Nobel Prize-winning British biochemists in 1906 

  • The availability of NAD+ has shown to promote DNA health and repair

  • NAD+ is required to deactivate genes that accelerate aging

  • Unfortunately, scientific studies show that NAD+ levels  decline significantly with age

  • Historically the most effective way to boost NAD+ was through expensive infusions; pills have been shown to be less effective

  • AgelessRx offers new methods of delivery (e.g. patch, nasal spray, injection, and cream) that are effective, less expensive and more convenient than other treatments

Longevity Benefits

  • Promotes cellular energy production 

  • Supports DNA health and repair

  • Required to “turn off” genes that accelerate degenerative aging processes

How it works on a cellular level in relation to aging

Nicotinamide adenine dinucleotide (NAD+) is an important cofactor in all living cells, involved in fundamental biological processes including metabolism, cell signalling, gene expression, DNA repair, and more.

 

Systemic NAD+ decline is one of the fundamental molecular events that negatively impacts the process of aging, potentially limiting lifespan.

  • NAD+ is required for energy production through metabolism, and helps turn nutrients into energy - without NAD+, we cannot make energy. 

  • NAD+ is required for energy production in every tissue, including the brain, immune cells, muscles, and more.

  • It is a required “helper” molecule for proteins that regulate other cellular functions.

  • Availability of NAD+ in the body promotes DNA repair, while NAD+ decline is associated with accumulation of DNA damage.

  • NAD+ levels decrease across multiple types of tissues with age, a factor associated with many hallmarks of aging.

AGING PATHWAYS IMPACTED

In 2013 a team of researchers broke down the causes of aging into 9 distinct scientific "hallmarks" (Aging Pathways) and explained how these interact with each other to drive the onset of age-related diseases.  ​

​Hallmarks Impacted by NAD​+

  • Genomic Instability

  • Epigenetic Alteration

  • Mitochondrial Dysfunction        

  • Cellular Senescence

9 Hallmarks of Aging

Genomic Instability

Telomere Attrition

Epigenetic Alteration

Loss of Proteostasis

Deregulated Nutrient Sensing

Mitochondrial Dysfunction

Cellular Senescence

Stem Cell Exhaustion

Altered Intercellular Communication

RESEARCH & STUDIES

"They focused on an intriguing compound with anti-aging properties called NAD+...It's been known that younger mice had more of it than older mice and back in 2013, the researchers found that when they boosted the NAD+ levels in older mice, they looked, biologically, like much younger animals." - TIME

Harvard Medical School Study Show NAD+ Boosting in Mice Decreased Aging

Longevity

When NAD+ levels rise, Sirtuins are activated. Sirtuins are enzymes that influence aging and longevity. They regulate a variety of metabolic processes, including the release of insulin, stress response, and modulation of lifespan.

The David Sinclair lab at Harvard Medical school has done extensive research into the benefits of NAD+ on aging and age related-diseases. Read the Studies

Source: Improving Health Through NAD+ Boosting - The Sinclair Lab

DNA Repair

When damaged, DNA activates an enzyme known as PARP-1 that carries out DNA repair within cells. NAD+ is required for PARP-1 to be activated.

PARP-1 activity correlates with maximum lifespan in mammals. The higher the PARP-1 activity, the longer the lifespan.  Read Full Study

Cells from centenarians (people who are at least 100 years old) show significantly higher PARP-1 activity levels than those of average 70 year olds. 

SAFETY INFORMATION

  • Since extra niacinamide needs to be methylated in order to be excreted, there is a theoretical need for extra methyl donors when using NAD+. We recommend using trimethylglycine (TMG also known as betaine), 500 to 1000mg, either daily, or at least on the days when the NAD+ patch is used. TMG is easily obtainable on Amazon or any other vitamin retailer.

PURCHASE NAD+ PRODUCTS

Starting at $25/Month

NAD+ INJECTION

  • 500 or 1,000/mg of NAD+ solution & syringes

  • Improves energy levels, mental clarity & mood

  • Effective in reducing cravings & fatigue

  • Improves post workout recovery

  • More cost-effective & convenient than IV infusions

  • Administered 1-3 times a week

Starting at $250

Starting at $250

NAD+ PATCHES

  • 400mg of NAD+ Solution per patch

  • Battery powered iontophoresis patch drives NAD+ absorption

  • Improves energy levels, mental clarity & mood

  • Supports DNA health and repair

  • Required to turn off genes that accelerate degenerative aging

  • Administered weekly 

Starting at $160/kit

Starting at $160/Kit

NAD+ NASAL SPRAY

  • 14 ml bottle with 300 mg/ml NAD+ concentration 

  • Improves energy levels, mental clarity & mood

  • Effective in reducing cravings & fatigue

  • Convenient way to boost brain NAD levels

  • Administered as needed

Starting at $125/Month

Starting at $125/Month

Starting at $95/Month

NAD+ FACE CREAM

  • 15 mg pump infused with 10% NAD+ concentration

  • Lessens appearance of wrinkles & age spots

  • Improves skin elasticity & firmness

  • Reduces sun sensitivity & future UV damage

  • Administered Daily

Starting at $95

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*If you are interested in a prescription product, AgelessRx will assist in setting up a visit for you with a licensed physician, who will evaluate whether or not you are an appropriate candidate for the prescription product. If appropriate, he/she may write you a prescription for the product which is fulfilled at a partnering pharmacy.