"If Rapamycin mechanism of action does not slow down aging then everything we know about biology is wrong"

Mikhail Blagosklonny PHD, MD


PEARL stands for the Participatory Evaluation of Aging with Rapamycin for Longevity. AgelessRx, in affiliation with the University of California, will soon launch this revolutionary, low-cost, and formalized scientific study to evaluate the safety and effectiveness of Rapamycin in healthy adults for longevity.

PEARL is a double-blind, randomized, placebo-controlled trial. Notably, it is the first nationwide telemedicine trial and the first large-scale intervention trial on longevity.

How PEARL Works

  • AgelessRx will enroll over 200-400 adults (50 years of age or older) for up to one year

  • Participants will be assigned to a specific dosage group or a placebo control group

  • Each participant will receive multiple tests throughout the trial valued at over $3,000

  • Ongoing doctor evaluation will be provided to each participant

  • Most advanced Biological Age Testing (methylation clocks)

  • Microbiome Test

  • Dexa Body Composition Testing

  • GlyconAge Test

  • Blood Panels with over 40 blood markers

  • Others

Tests That Participants will get Include:

Introduction to Rapamycin for Longevity

"The overwhelming evidence suggests that rapamycin is a universal anti-aging drug"

- Mikhail Blagosklonny PHD, MD


“For persons over 50, it it most the important drug in the world today”

- Alan Green, MD


“…rapamycin is currently the most effective and reproducible pharmacological approach for directly targeting the aging process to increase life span…”

- Matt Kaeberlein, PHD

Many Thanks to Our Esteemed Supporters, Sponsors & Collaborators

Mikhail V. Blagosklonny, M.D., PhD

James Watson,

Read More

Joshua Rosenthal,

Alan S Green,


Rapamycin Press

Better Humans




Make a Donation or Sponsor PEARL Trial

In order to get the PEARL Trial off the ground we are looking for ​donors and sponsors. 

Have you wished a trial like this happened long time ago? Do you believe that this trial could be a meaningful step forward for the longevity movement? Please consider becoming a sponsor, and making this a reality sooner.


  • Welcome $100+

  • You will be kept informed of progress and results

  • Tax-deductible


  • Donations of $5K or more

  • You or company logo listed in the sponsor section

  • Co-authorship opportunities

  • Tax-deductible