PEARL TRIAL

"If Rapamycin mechanism of action does not slow down aging then everything we know about biology is wrong"

Mikhail Blagosklonny PHD, MD

Overview

PEARL stands for the Participatory Evaluation of Aging with Rapamycin for Longevity. AgelessRx, in affiliation with the University of California, will soon launch this revolutionary, low-cost, and formalized scientific study to evaluate the safety and effectiveness of Rapamycin in healthy adults for longevity.

PEARL is a double-blind, randomized, placebo-controlled trial. Notably, it is the first nationwide telemedicine trial and the first large-scale intervention trial on longevity.

How PEARL Works

  • AgelessRx will enroll over 200-400 adults (50 years of age or older) for up to one year

  • Participants will be assigned to a specific dosage group or a placebo control group

  • Each participant will receive multiple tests throughout the trial valued at over $3,000

  • Ongoing doctor evaluation will be provided to each participant

Tests That Participants will get Include:

  • Most advanced Biological Age Testing (methylation clocks)

  • Microbiome Test

  • Dexa Body Composition Testing

  • GlyconAge Test

  • Blood Panels with over 40 blood markers

  • Others

PEARL Registry

Already taking rapamycin? Please consider joining our PEARL Registry.

  • Receive monthly and quarterly surveys similar to those that the PEARL Trial participants receive.

  • Gain access to purchase any or all of the available tests that our trial participants receive.

  • Provide important insight into rapamycin use and aging

Introduction to Rapamycin for Longevity

"The overwhelming evidence suggests that rapamycin is a universal anti-aging drug"

- Mikhail Blagosklonny PHD, MD


 

“For persons over 50, it it most the important drug in the world today”
 

- Alan Green, MD


 

“…rapamycin is currently the most effective and reproducible pharmacological approach for directly targeting the aging process to increase life span…”

- Matt Kaeberlein, PHD

Many Thanks to Our Esteemed Supporters, Sponsors & Collaborators

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Mikhail V. Blagosklonny, M.D., PhD

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James Watson,
M.D.

Read More

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Joshua Rosenthal,
MScEd

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Alan S Green,
M.D.

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Rapamycin Press

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Better Humans

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Lifespan.IO

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AgeCurve

Make a Donation or Sponsor PEARL Trial

In order to get the PEARL Trial off the ground we are looking for ​donors and sponsors. 

Have you wished a trial like this happened long time ago? Do you believe that this trial could be a meaningful step forward for the longevity movement? Please consider becoming a sponsor, and making this a reality sooner.

DONATE TO PEARL

  • Welcome $100+

  • You will be kept informed of progress and results

  • Tax-deductible

BECOME A KEY SPONSOR

  • Donations of $5K or more

  • You or company logo listed in the sponsor section

  • Co-authorship opportunities

  • Tax-deductible

Thank You to Our Donors

A special thank you to our additional supporters; thanks for joining the cause!

Robert Adams


Ken Alexander


Yerai Alonso Febles

Christopher Alvarez


Edward Anderton


James Andreas


Michael Andreychik


Michael Antonov


Robert Arbetter


Leroy Arellano

Brad Armstrong


Rami Atoot


Linda Backman


Sash Balasinkam


Adam Balazs


Lanny Ballard


Mike Barraclough


Kevin Bärudde


Bertrand Bazire


Michael Beasley


Fred Bell


Koensgen Benjamin


Kyle Benkendorfer


Maximilian Berger


Bryan Bessaud


Randy Blumhoff


Richard Boenigk


Paul Böhringer


Eduard Boiko


Ilya Borisov


Mike Bosse


Boyan Botyov


Donovan Breone


Marc Bresenoff


Jason Brisbois


Amy Britton


ZedAron Burnett


Bernhard Buss


Vitalik Buterin


Michael Camacho


Jon Carder


Greg Chappell


Nathan Cheng


Bruce Chou


Tawfiq Choudhury


Neil Christensen


Lars Claussen


Josh Clemente


Mat Cloutier


Edward Coach


Didier Coeurnelle


Kym Connolly


Jonathan Cooper


Ivan Corona


Ana Costa


Duley Crabbe


Dylan Craine


Christopher Crewdson


Hector Cuesta


Mahdi Daraei


Artur Davidian


John Davids


George Davis


Paul Davis


Bear Days


Siegfried De Bleeckere


Nuno Miguel de Brito Delgado


Erard de Hemricourt


Jonathan De Zoete


Dwayne DeBardelaben


Steve Delgrange


Itzhak Dershowitz


Breanna Deutsch


Kara Devar


William Devore


Katherine Dodds


Doug Doherty


Vincenzo Domina


Grigory Dorokhov


Natalia & Tim Drohan


Vladimir Dubinsky


Alejandro Dubrovsky


Matteo Durante


Zane Dush


Bogdan Dziewierz


Áron Ecsedy

Rickard Edén

Johan Edholm


Emil Edman Hellberg


Daniel Eisenman


Janis Elsts


Jonathan Engborg


Lawrence Engleman


Balint Erdi


Aurora Ermon


Joshua Farahzad


Jellycat Fish


Matthias Fleischer


Moncomble Florian


Joe Franks


Dimitriou Frideriki


Derek Friedhoff


Alfred Fulbright


Edward Galimi


John D Gauchat


Bill Gelpi


Louis Gerrue


Alex Gewecke


Viktor Glazunov


David Gougeon


Ed Graham


Marcelo Granja


Kyle Griffiths


Jose Guerrero


Vincent Guyette

Jonathan Hales

Edward Hall


Peter Hall


Linda Hannus


Kjersti Hansen


Chris Hardin


Richard Harvey


Dan Healy


David Hedenrud


Sebastian Heizmann


Louis Helm


Austin Henderson


Brian Henderson


Luc Hendriks


Lukas Henschke


Jukka Hervamaa


Kevin Higgins


Dan Hightower


Chris Hill


Gary Hirst


Lance Hitchings


Simon Holk


Sam Holmes


James Howarth


Adam Hruby


Tyler Hruby


Matthew Hussey


Stefanie Huthmacher


Trent Hutton


Abdul Ibrahim


Liam Iles


Jerry Irwin


Anar Isman


Vasya Ivanov


Bob Jacobs


Soheila Jalali


Robert Jenner


Anthony Jennings


Timothy Jensen


Christopher Johnson


Jake Jones


Kevin Ju
 

David Jung
 

Ben Kamens
 

Andreas Kammerer
 

Ivan Karlovich
 

Neil Kauffman
 

James Kelly
 

David Kelly
 

Yoel Kelman
 

Jerry Kimpton
 

Kevin Kin
 

Jamie Knight
 

Richard Kollen
 

Sven Konermann


Keenan Kornegay
 

Iason Koukas
 

Alexey Kovyazin

Gregers Krabbe

Ryan Kraudel
 

Terrence Kulasa
 

Vince L
 

Styn Labeeuw
 

Michael Lai
 

Barbara Lamar
 

Mark Lambert
 

Gloria Landeta
 

Sam Larke
 

Gregory Larrimore
 

Jordan Laurent
 

Corry Lazarowitz
 

John Leahy
 

Hong Lee
 

Timothy Leonard
 

Bary Levy
 

Sam Lidman
 

Chris Linnell
 

Kyle Litwin
 

Ilkka Liukas
 

Jonathan Lobatto
 

Miguel Lopes
 

Richard Ludka
 

Jake Mabey
 

Justin Magiera
 

Bella Maillet
 

Stephen Malina
 

Luca Martini
 

Darin Matsumoto
 

Tim Maupin
 

Art Maurice
 

Chris Mcaulay
 

Matt McCormack
 

Adam McDonald
 

Patrick McNulty
 

Ray Melissa
 

Franco Mendoza
 

Gokhan Mergen
 

Whit Miller
 

Oren Milman
 

Nick Mitsakis
 

Michael Möhle
 

Gabor Molnar
 

Tom Murtagh
 

Satya N
 

Chuong Nguyen
 

Albert Nigrin
 

Sofya Nikolaeva
 

Nico NVH
 

Manpj Obama
 

William Oshea
 

Gisbert Oskam
 

Mary Ott
 

Christopher Ottesen
 

Bogdan Padiu
 

Tim Padvitski
 

Guilherme Paioa

David Palesch

Andrei Pancu
 

Matej Pankovcin
 

Richard Parton
 

Chirag Pattni
 

Danny Peeters
 

Viktoriya Perepletkina
 

Fred Perry
 

Svensson Peter
 

Luis Petersen
 

Linus Petersson
 

Aleksandr Petukhov
 

Mallory Phillips
 

Simon Pilkington
 

Jim Plante
 

Anton Pols
 

Aleksandr Popov
 

Robert Powles
 

Alexandra Preston
 

Tristram Price
 

Silvia Prieto
 

Fabio Quirici
 

David Race
 

Michael Rae
 

Ferdinando Randisi
 

Steve Randolph
 

Robert Rangel
 

Rino Ras
 

Rasmus Rasch

Tobias Ratschiller

Chris Rau
 

Thimma Reddi
 

Nils Regge
 

Jan Renter
 

Robert Reyes
 

Christopher Reynolds
 

James Rice
 

Savannah Rice
 

Robert Ringelberg
 

Mathias Rochus
 

Jason Roeschley
 

Robin Rose
 

David Rosenberg
 

James Rubin
 

Corbin S.
 

Dmitry Sadovnikov
 

Helie Sadovsky
 

Benjamin Santiago
 

Richard Sapp
 

Laurent Saunier
 

Tom Moya Schau
 

Ariel Schön
 

Fabian Schrötter
 

Eric Schulke
 

James Schultz
 

Jack Shahin
 

Neuro Shark
 

Henry Shaw
 

Oleksandr Shmidt
 

Nicholas Singh
 

Konstantin Sinkevich
 

Scott Slotterbeck
 

Shlomo Small
 

Daniel Smith
 

Sarah Smith
 

Richard Smith
 

Jack Smith
 

Paul Spiegel
 

Jay Springfield
 

Stephen Stanton-Downes
 

Kavin Stewart
 

Gennady Stolyarov
 

Rob Stone
 

Howard Story
 

Dominic Strandemo
 

Robert Suchan
 

Balazs Suhajda
 

Richard A Sundvall
 

Peter Svensson
 

Jesse Tanner
 

Curry Taylor
 

Transhuman Tees
 

Brian Temerowski
 

Hal Tepfer
 

Robert Tessier
 

Michael Todhunter
 

Shane Tolmie
 

Anna Tonkonogui
 

Simon Tost
 

Dustin D. Trammell
 

Andrew Tress
 

William Trevino
 

David Troy
 

Emiel van der Horst
 

Ernst Van Graan
 

Neil Vasilakes
 

Brian Vaughn
 

Gerardo Vazquez de Miguel
 

Alex Vlasov
 

Shannon Vyff
 

Steve Waddell
 

Mike Wallach
 

Oliver Ward
 

Vincent Weisser
 

Michael Wester
 

Olivia White
 

Sebastian Wieber
 

Robert Wilkes
 

John Wimer
 

Jordan Windsor
 

Ben Wu
 

Jeff Zaroyko
 

Michael Zenkl
 

David Zhang
 

Mattia Zirpoli
 

Micah Zoltu
 

Miha Zorc