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DMAE for Aging Skin


DMAE Firming Gel
DMAE can help to reverse the signs of aging skin.

In this blog post, we explore:

  • What DMAE is

  • Anti-aging benefits of DMAE

  • The science behind DMAE

  • Important safety information before using DMAE


What is DMAE?

DMAE stands for dimethyaminoethanol (deanol for short). It’s an organic compound and peptide that’s been shown to tighten and firm facial and neck skin dramatically. It’s also been clinically proven to increase dermal (skin) thickness while also hydrating better than many OTC moisturizing products. Used consistently, DMAE can have acute skin-firming effects.


Researchers say: “DMAE (an analog of the B vitamin choline and a precursor of acetylcholine) has been receiving more attention as an exciting new skincare supplement today for its acute effects of anti-aging, anti-wrinkle and skin firmness.”


DMAE is naturally produced in the human body. It’s also found in fatty fish (such as salmon, sardines, and anchovies). It is generally safe for all skin types, even the most sensitive.


What are the anti-aging benefits of DMAE?

DMAE fights visible signs of aging skin by increasing the production of Acetylcholine, a neurotransmitter crucial for helping nerve cells send signals. This helps to tighten and firm the skin, while providing hydration and unifying skin tones. As a result, DMAE can provide a slew of anti-aging beignets for skin:

  • Highly effective firming agent for tired & sagging skin

  • Tightens and firms crepey neck, crow’s feet & forehead lines

  • Diminishes dark under-eye circles

  • Improves lip shape and fullness

  • Tightens nasolabial folds to firm skin on face & neck

  • Hydrates better than most fillers or injections

  • Helps to builds back the skin barrier we’ve lost to age


What’s the science behind DMAE?

Over the last 15 years, DMAE has continued to gain traction in the skin care industry as an ally to combat the visible signs of aging skin. Until 2021, it was never offered as a prescription (AgelessRx is the first to offer DMAE as a firming gel).


While published clinical studies are somewhat limited—DMAE for aging skin is still somewhat “new” by industry standards—the ongoing positive results from these studies along with continued support from dermatologists and skin care experts around the world echo its many benefits:

  • In a randomized clinical trial, DMAE facial gel applied daily for four months showed reduction in forehead lines and periorbital fine wrinkles. Beneficial trends were noted in the appearance of coarse (deeper) wrinkles, under-eye dark circles, nasolabial folds (laugh lines), sagging neck skin, and neck firmness.

  • The same study showed users had improved lip shape and fullness, too.

  • In a 2005 clinical study published in the American Journal of Clinical Dermatology, DMAE showed potential as an ingredient that could actually penetrate under the skin and improve underlying facial muscle tone.

  • In a 2014 study published in the Scientific World Journal, “Those treated with 0.2% DMAE showed epidermal and dermal thickness and density of collagen fiber that was significantly elevated over those of aging control groups after just 42 days.”

What should I know before starting DMAE?

Before starting any new prescription, be sure to tell your doctor or healthcare provider about all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements.

You should not use topical DMAE if you take any of the following medications: acetylcholinesterase inhibitors (i.e. Aricept, Cognex, Reminyl), anticholinergic medications (used for Parkinson’s Disease, COPD, and overactive bladder), cholinergic medications (used for Alzheimer’s and glaucoma), anticoagulants (i.e. blood thinners).


Do not use DMAE if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether they are pregnant). Additionally, people with an allergy to fish or fish products, DMAE, or any of its ingredients, should not take DMAE.


For more information on possible side effects, possible drug interactions, and more, click here.


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To learn more, or to request a DMAE Firming Gel prescription, click here.



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